Lipidomic profiling reveals early-stage metabolic dysfunction in overweight or obese humans.

Affiliation

Metabolomics Laboratory, Baker Heart and Diabetes Institute, 75 Commercial Road, Melbourne, VIC 3004, Australia. Electronic address: [Email]

Abstract

Advances in mass spectrometry and lipidomics techniques are providing new insights into the role of lipid metabolism in obesity-related diseases. However, human lipidomic studies have been inconsistent, owing to the use of indirect proxy measures of metabolic outcomes and relatively limited coverage of the lipidome. Here, we employed comprehensive lipid profiling and gold-standard metabolic measures to test the hypothesis that distinct lipid signatures in obesity may signify early stages of pathogenesis toward type 2 diabetes.

Keywords

Diabetes,Insulin secretion,Lipid metabolism,Lipidomics,Metabolic dysfunction,Obesity,

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