Loss of Sox9 in cardiomyocytes delays the onset of cardiac hypertrophy and fibrosis.

Affiliation

Department of Internal Medicine and Cardiology, University Hospital, TU Dresden, Germany. Electronic address: [Email]

Abstract

The transcription factor Sox9 has been associated with cardiac injury and remodeling. Studies of mammalian hearts confirm Sox9 upregulation in fibroblasts following ischemic insults associated with enhanced fibrosis. The role of cardiomyocyte-specific Sox9 remains unclear. This study aimed to evaluate the role of cardiomyocyte-specific Sox9 in development and progression of left ventricular (LV) hypertrophy and fibrosis.

OUR Recent Articles