Medial prefrontal disengagement during self-focus in formerly depressed patients prone to rumination.


AP-HP, Hôpitaux Universitaires Paris Ouest, Service de Psychiatrie de l'adulte et du sujet âgé, Paris, France; Child and Adolescent Mental Health Centre, Capital Region Psychiatry, Copenhagen, Denmark; Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Denmark; Translational Medicine, Clinical Pharmacology & Translational Medicine, Novo Nordisk A/S. Electronic address: [Email]


Medial prefrontal cortex (MPFC) activity during self-referential processing has been associated with rumination and found aberrant in depression. We investigated whether this aberrant activity reflects a trait marker that persists in remitted patients.


FMRI,Major depressive disorder,Medial prefrontal cortex,Remission,Rumination,

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