Medial septal stimulation increases seizure threshold and improves cognition in epileptic rats.


Department of Neurological Surgery, University of California, Davis, USA; Center for Neuroscience, University of California, Davis, USA. Electronic address: [Email]


Temporal lobe epilepsy is most prevalent among focal epilepsies, and nearly one-third of patients are refractory to pharmacological intervention. Persistent cognitive and neurobehavioral comorbidities also occur due to the recurrent nature of seizures and medication-related side effects.


Deep brain stimulation,Medial septal nucleus,Pilocarpine,Temporal lobe epilepsy,Theta oscillations,