Messenger RNA Modifications in Plants.

Affiliation

Temasek Life Sciences Laboratory, 1 Research Link, National University of Singapore, 117604, Singapore; These authors contributed equally to this manuscript. Electronic address: [Email]

Abstract

Over 160 distinct RNA modifications are known and collectively termed the epitranscriptome. Some of these modifications have been discovered in mRNA, uncovering a new layer of gene regulation. Transcriptome-wide mapping of epitranscriptomic codes and the discovery of their writers, erasers, and readers that dynamically install, remove, and interpret RNA modifications, respectively, are fundamental to understanding the epitranscriptome. Recent technologies have enabled the transcriptome-wide profiling of several mRNA modifications in Arabidopsis thaliana, providing key insights into regulating these modifications and their effects on plant development. Here we review technological innovations and recent progress in epitranscriptomics, with specific focus on N6-methyladenosine (m6A), 5-methylcytosine (m5C), uridylation, and their roles in multiple aspects of plant development.

Keywords

Arabidopsis,RNA modification,epitranscriptome,m(5)C,m(6)A,uridylation,

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