Metabolic derangements of skeletal muscle from a murine model of glioma cachexia.


Department of Physical Education, Xiamen University of Technology, 600 Ligong Road, Jimei District, Xiamen, 361024, China. [Email]


Cachexia is a complex metabolic disorder and muscle atrophy syndrome, impacting 80% patients with advanced cancers. Malignant glioma is considered to be one of the deadliest human cancers, accounting for about 60% of all primary brain tumors. However, cachexia symptoms induced by glioma have received little attention. This work aims to explore skeletal muscle atrophy in orthotopic glioma murine models.


Animal model,Glioma cachexia,Malignant grades,Metabolic derangements,Muscle atrophy,Skeletal muscle metabolism,