Mitochondrial DNA haplogroups affect physical performances in Han older adults: an 8-year follow-up prospective cohort study.

Affiliation

Yang CW(1), Li CI(1)(2), Chang JG(2)(3), Liu CS(2)(4), Lin CH(2)(4), Lin WY(2)(4), Li TC(5)(6), Lin CC(1)(2)(4).
Author information:
(1)Department of Medical Research, China Medical University Hospital, Taichung, Taiwan.
(2)School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan.
(3)Epigenome Research Center, China Medical University Hospital, Taichung, Taiwan.
(4)Department of Family Medicine, China Medical University Hospital, Taichung, Taiwan.
(5)Department of Public Health, College of Public Health, China Medical University, Taichung, Taiwan.
(6)Department of Healthcare Administration, College of Medical and Health Sciences, Asia University, Taichung, Taiwan.

Abstract

AIM: The objective of this study was to explore the association between mitochondrial DNA (mtDNA) haplogroups and physical performances in Han older adults. METHODS: This study was an 8-year follow-up prospective cohort study. A total of 104 Han older adults completed the measurements of the 6-min walk test, grip strength and mitochondrial DNA sequencing. The mtDNA haplogroups were classified by using HaploGrep2 software. We used the mixed model to analyze the longitudinal effect of mtDNA haplogroups on physical performance tests among three waves of data. RESULTS: The mean age at wave 3 among men and women were 78.3 and 77.2 years, respectively. The overall proportions of mtDNA haplogroups in this study population was 26.9% F, 21.2% M, 15.4% R, 14.4% D, 8.7% B and others. After adjusted for age, sex, ethnicity, body mass index and exercise, the interaction of mtDNA haplogroup M and waves significantly affected the 6-min walk distance. Notably, the adjusted mean of the 6-min walk distance among the group of mtDNA haplogroup M was significantly lower than other haplogroups at wave 3. The adjusted mean of grip strength among the group of mtDNA haplogroup R was significantly higher than other haplogroups at wave 3. CONCLUSIONS: This finding suggests that mtDNA haplogroups might have effects on the 6-min walk test and grip strength in Han older adults, although studies of the physical performance of older adults with larger sample sizes are necessary to further substantiate these findings. Geriatr Gerontol Int 2021; 21: 166-171.