Modulation of cyclic topology toward enhanced drug delivery, from linear and tadpole-like to dumbbell-shaped copolymers.


State Key Laboratory of Applied Organic Chemistry, Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, Gansu 730000, China. [Email]


In this study, an efficient strategy for the synthesis of dumbbell-shaped amphiphilic copolymers with cyclic moieties as the two bells was developed and the enhanced performance of dumbbell-shaped copolymers for controlled drug release because of the simultaneous introduction of two macrocycles was disclosed.

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