Monocytes-neutrophils-ratio as predictive marker for failure of first induction therapy in AML.

Affiliation

Department of Medicine, Knappschaftskrankenhaus Bochum-Langendreer, Ruhr University Bochum, Germany; Center of Clinical Research, Department of Molecular GI-Oncology, Ruhr University Bochum, Germany. Electronic address: [Email]

Abstract

Acute myeloid leukemia (AML) is, if untreated, a fatal hematologic neoplasia. Failure of the first induction chemotherapy is a hallmark for a poor prognosis. Early recognition of therapy failure is crucial for planning further therapies. Therefore, international guidelines recommend a bone marrow biopsy around day 14 after the beginning of induction therapy. Hypocellular bone marrow on day 14 is still gold standard for therapy assessment and further therapy strategy. Despite this, non-invasive ways for the evaluation of induction therapy were looked for in the past years.

Keywords

AML,Induction therapy,Monocytes,Neutrophils,Predictive marker,