New insights into the role of the Nrf2 signaling pathway in green tea catechin applications.


Talebi M(1), Talebi M(2)(3), Farkhondeh T(4)(5), Mishra G(6), İlgün S(7), Samarghandian S(8).
Author information:
(1)Department of Pharmacognosy and Pharmaceutical Biotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
(2)Department of Chemistry and Biochemistry, University of Texas at Arlington, Arlington, Texas, USA.
(3)Department of Research & Development, Viatris Pharmaceuticals Inc., San Antonio, Texas, USA.
(4)Medical Toxicology and Drug Abuse Research Center
(MTDRC), Birjand University of Medical Sciences, Birjand, Iran.
(5)Faculty of Pharmacy, Birjand University of Medical Sciences, Birjand, Iran.
(6)Institute of Medical Sciences, Faculty of Ayurveda, Department of Medicinal Chemistry, Banaras Hindu University, Varanasi, India.
(7)Department of Pharmaceutical Botany, Faculty of Pharmacy, Erciyes University, Kayseri, Turkey.
(8)Noncommunicable Diseases Research Center, Neyshabur University of Medical Sciences, Neyshabur, Iran.


Nuclear factor-erythroid 2-related factor 2 (Nrf2) is a transcriptional signaling pathway that plays a crucial role in numerous clinical complications. Pivotal roles of Nrf2 have been proved in cancer, autoimmune diseases, neurodegeneration, cardiovascular diseases, diabetes mellitus, renal injuries, respiratory conditions, gastrointestinal disturbances, and general disorders related to oxidative stress, inflammation, apoptosis, gelatinolysis, autophagy, and fibrogenesis processes. Green tea catechins as a rich source of phenolic compounds can deal with various clinical problems and manifestations. In this review, we attempted to focus on intervention between green tea catechins and Nrf2. Green tea catechins especially epigallocatechin gallate (EGCG) elucidated the protective role of Nrf2 and its downstream molecules in various disorders through Keap-1, HO-1, NQO-1, GPx, GCLc, GCLm, NF-kB cross-link, kinases, and apoptotic proteins. Subsequently, we compiled an updated expansions of the Nrf2 role as a gate to manage and protect different disorders and feasible indications of green tea catechins through this signaling pathway. The present review highlighted recent evidence-based data in silico, in vitro, and in vivo studies on an outline for future clinical trials.