New octadecanoid derivatives from the seeds of Ipomoea nil.

Affiliation

School of Biological Science and Technology, University of Jinan, Jinan 250022, China. Electronic address: [Email]

Abstract

Four new octadecanoid derivatives (1-4) including a pair of enantiomers (1/2), along with 12 known analogues (5-16), were isolatedfrom the seeds of Ipomoea nil. Their structures were determined by detailed spectroscopic analyses and comparison with reported data of structurally related compounds, with the absolute configurations of 1 and 2 being assigned by an in situ dimolybdenum ECD method. Our bioassays revealed that these isolates did not show ABTS radical scavenging activity while 10 and 13 displayed better α-glucosidase inhibitory activity than the positive control acarbose (IC50 167.7 ± 1.55 μmol·L-1), with IC50 of 92.73 ± 3.12 and 11.39 ± 2.18μmol·L-1, respectively.

Keywords

Fatty acid,Ipomoea nil,Natural enantiomer,Octadecanoid,α-Glucosidase inhibition,

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