Hefei National Laboratory for Physical Sciences at the Microscale , CAS Key Laboratory of Urban Pollutant Conversion , Anhui Province Key Laboratory of Biomass Clean Energy , iChEM , University of Science and Technology of China , Hefei 230026 , China . Email: [Email] ; Email: [Email]
Herein, we report a nickel-catalyzed allylic defluorinative alkylation of trifluoromethyl alkenes through reductive decarboxylation of redox-active esters. The present reaction enables the preparation of functionalized gem-difluoroalkenes with the formation of sterically hindered C(sp3)-C(sp3) bonds under very mild reaction conditions, while tolerating many sensitive functional groups and requiring minimal substrate protection. Therefore, this method provides an efficient and convenient approach for late-stage modification of biologically interesting molecules.
