Non-invasive assessment of placental perfusion in vivo using arterial spin labeling (ASL) MRI: A preclinical study in rats.

Affiliation

INSERM, U970, Sorbonne Paris Cite, Paris Cardiovascular Research Center - PARCC, Paris, France; Assistance Publique-Hôpitaux de Paris, Hôpital Necker-Enfants Malades, Paris, France; EA 7328 FETUS, Université Paris Descartes, France; Lumiere Project, France. Electronic address: [Email]

Abstract

Non-invasive assessment of placental perfusion is of great interest to characterize placental function in clinical practice. This article proposes a strictly non-invasive MRI technique using ASL to quantify placental blood flow in vivo. The aim of this study was to develop a fMRI tool to quantify placental blood flow (PBF) in rat, by using arterial spin labeling (ASL) MRI at 4.7 T.

Keywords

Arterial spin labeling,Functional MRI,Microcirculation,Perfusion,Placenta,