Novel methods for the quantification of toxic, residual phase transfer catalyst in fluorine-18 labeled radiotracers.

Affiliation

The University of Tennessee Graduate School of Medicine, 1924 Alcoa Hwy., Knoxville, TN 37920, United States of America. Electronic address: [Email]

Abstract

Fluorine-18 labeled radiopharmaceuticals undergo quality control testing for residual phase-transfer-catalyst content. The almost universally used quality-control test is a silica plate spot-test comparison of the radiopharmaceutical beside a 50-ppm standard. Once developed by staining, the radiopharmaceutical spot must be of equal or less intensity to pass the test. There is currently a need for a quantitative, inexpensive, and less subjective quality control method that allows the automatic incorporation of the acquired measurement directly into electronic batch reports.

Keywords

Absorbance,Conductance,Phase-transfer-catalyst,Radiopharmaceutical,Transmittance,

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