Nucleus-Invadopodia Duo During Cancer Invasion.

Affiliation

Institut Curie, PSL Research University, CNRS, UMR 144, 26 rue d'Ulm, F-75005, Paris, France. Electronic address: [Email]

Abstract

Matrix proteolysis mediated by MT1-MMP facilitates the invasive migration of tumor cells in dense tissues, which otherwise get trapped in the matrix because of limited nuclear deformability. A digest-on-demand response has been identified, which requires nucleus-microtubule linkage through the LINC complex and triggers MT1-MMP surface-exposure to facilitate nucleus movement.

Keywords

LINC complex,MT1-MMP,centrosome,invadopodia,microtubule,tumor invasion,

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