Hyun S(1), Park N(2), Nam SH(3), Cheon DH(3), Lee Y(3), Lim HS(4), Yu J(2). Author information:
(1)The Institute of Molecular Biology & Genetics, Seoul National University,
Seoul 08826, Korea.
(2)Department of Chemistry & Education, Seoul National University, Seoul 08826,
(3)Department of Chemistry, Seoul National University, Seoul 08826, Korea.
(4)Department of Chemistry, Pohang University of Science and Technology, Pohang
37673, Korea. [Email]
In an effort designed to discover superior inhibitors of cyclophilin D (CypD), we identified and screened members of a one-bead-one-compound (OBOC) library of cyclic peptoid analogues of cyclosporin A (CsA). The results show that the one member of this cyclic peptoid family, I11, inhibits mitochondrial membrane potential changes mediated by CypD.
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