Overdose following initiation of naltrexone and buprenorphine medication treatment for opioid use disorder in a United States commercially insured cohort.


Department of Medicine, Section of Infectious Diseases, Boston Medical Center, 801 Massachusetts Avenue Boston, MA, 02118, USA. Electronic address: [Email]


Despite the growing opioid overdose crisis, medication treatment for opioid use disorder remains uncommon. The comparative effectiveness of buprenorphine and naltrexone treatment in reducing overdose and the comparative risks of discontinuing treatment in the real world, remain uncertain. Our aim was to examine the effectiveness of medications for opioid use disorder in preventing opioid-related overdose.


Buprenorphine,Injectable naltrexone,Opioid use disorder,Oral naltrexone,Overdose,