PET/Computed Tomography in Chronic Lymphocytic Leukemia and Richter Transformation.


Division of Hematology and Oncology, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA. Electronic address: [Email]


Chronic lymphocytic leukemia (CLL) is the most common leukemia in the United States. In 1-10% of cases, it can undergo Richter's transformation (RT) to either diffuse large B cell lymphoma (DLBCL) or Hodgkin's lymphoma (HL). Diagnosis requires histologic confirmation by tissue biopsy. PET/CT has been studied to in several series to look at its predictive value for identifying RT in biopsies. in this review, we will discuss the role of PET/CT to identify RT in patients CLL and its utility in clinical practice.


Accelerated CLL,B-cell receptor inhibitor,Chronic lymphocytic leukemia,Ibrutinib,PET/CT,Richter transformation,Venetoclax,