Pancreatic cancer treated with SBRT: Effect of anatomical interfraction variations on dose to organs at risk.


Department of Radiotherapy, Erasmus MC University Medical Centre, Rotterdam, the Netherlands. Electronic address: [Email]


Interfraction shape and position variations of organs at risk (OARs) may increase uncertainty in dose delivery during stereotactic body radiotherapy (SBRT), potentially leading to overirradiation or concessions in planned tumor dose and/or coverage to prevent clinical constraints violation. The aim of our study was to quantitatively analyze the impact of anatomical interfraction variations on dose to OARs in pancreatic cancer (PC) treated by SBRT using a CyberKnife with integrated CT-on-rails.


Dosimetry,Interfraction variation,Organ motion,Pancreatic cancer,SBRT,

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