Patient-tailored antithrombotic therapy following percutaneous coronary intervention.

Affiliation

van der Sangen NMR(1), Rozemeijer R(2), Chan Pin Yin DRPP(3), Valgimigli M(4)(5), Windecker S(5), James SK(6), Buccheri S(6), Ten Berg JM(3)(7), Henriques JPS(1), Voskuil M(2), Kikkert WJ(1)(8).
Author information:
(1)Department of Cardiology, Amsterdam UMC, University of Amsterdam, Amsterdam Cardiovascular Sciences, Meibergdreef 9, 1105 AZ Amsterdam, the Netherlands.
(2)Department of Cardiology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, the Netherlands.
(3)Department of Cardiology, St. Antonius Hospital, Koekoekslaan 1, 3435 CM Nieuwegein, the Netherlands.
(4)Department of Cardiology, Cardiocentro Ticino, Via Tesserete 48, 6900 Lugano, Switzerland.
(5)Department of Cardiology, Bern University Hospital, Freiburgstrasse 18, 3010 Bern, Switzerland.
(6)Department of Medical Sciences and Uppsala Clinical Research Center, Uppsala University, Dag Hammarskjölds Väg 38, 751 85 Uppsala, Sweden.
(7)Department of Cardiology, University Medical Center Maastricht, P. Debyelaan 25, 6229 HX Maastricht, the Netherlands.
(8)Department of Cardiology, Onze Lieve Vrouwe Gasthuis, Oosterparkstraat 9, 1091 AC Amsterdam, the Netherlands.

Abstract

Dual antiplatelet therapy has long been the standard of care in preventing coronary and cerebrovascular thrombotic events in patients with chronic coronary syndrome and acute coronary syndrome undergoing percutaneous coronary intervention, but choosing the optimal treatment duration and composition has become a major challenge. Numerous studies have shown that certain patients benefit from either shortened or extended treatment duration. Furthermore, trials evaluating novel antithrombotic strategies, such as P2Y12 inhibitor monotherapy, low-dose factor Xa inhibitors on top of antiplatelet therapy, and platelet function- or genotype-guided (de-)escalation of treatment, have shown promising results. Current guidelines recommend risk stratification for tailoring treatment duration and composition. Although several risk stratification methods evaluating ischaemic and bleeding risk are available to clinicians, such as the use of risk scores, platelet function testing , and genotyping, risk stratification has not been broadly adopted in clinical practice. Multiple risk scores have been developed to determine the optimal treatment duration, but external validation studies have yielded conflicting results in terms of calibration and discrimination and there is limited evidence that their adoption improves clinical outcomes. Likewise, platelet function testing and genotyping can provide useful prognostic insights, but trials evaluating treatment strategies guided by these stratification methods have produced mixed results. This review critically appraises the currently available antithrombotic strategies and provides a viewpoint on the use of different risk stratification methods alongside clinical judgement in current clinical practice.

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