Pattern recognition receptors as potential therapeutic targets in metabolic syndrome: From bench to bedside.

Author

Amanda Almeida de Oliveira

Affiliation

Department of Biomedical and Chemical Engineering and Sciences, Florida Institute of Technology, Melbourne, USA. Electronic address: [Email]

Abstract

Pattern recognition receptors (PRRs) such as Toll-like receptors (TLRs) and NOD-like receptors (NLRs) play crucial roles in the underlying mechanisms of metabolic syndrome (MetS). Mainly, these receptors have been suggested to participate in the pathophysiological processes involved in the complications associated with this condition. Therefore, to evolve therapeutic strategies targeting PRRs might be an imperative approach to avoid the development of further complications in human subjects. In this work, we discuss the understanding regarding the roles of PRRs in the pathways of MetS to further describe potential advancements made to target these receptors within this pathology.

Keywords

Metabolic syndrome,NLRs,TLRs,Therapeutic targets,