Phase separation of DNA: From past to present.

Affiliation

King JT(1), Shakya A(2).
Author information:
(1)Center for Soft and Living Matter, Institute for Basic Science, Ulsan, Republic of Korea. Electronic address: [Email]
(2)Center for Soft and Living Matter, Institute for Basic Science, Ulsan, Republic of Korea. Electronic address: [Email]

Abstract

Phase separation of biological molecules, such as nucleic acids and proteins, has garnered widespread attention across many fields in recent years. For instance, liquid-liquid phase separation has been implicated not only in membraneless intracellular organization but also in many biochemical processes, including transcription, translation, and cellular signaling. Here, we present a historical background of biological phase separation and survey current work on nuclear organization and its connection to DNA phase separation from the perspective of DNA sequence, structure, and genomic context.