King JT(1), Shakya A(2). Author information:
(1)Center for Soft and Living Matter, Institute for Basic Science, Ulsan,
Republic of Korea. Electronic address: [Email]
(2)Center for Soft and Living Matter, Institute for Basic Science, Ulsan,
Republic of Korea. Electronic address: [Email]
Phase separation of biological molecules, such as nucleic acids and proteins, has garnered widespread attention across many fields in recent years. For instance, liquid-liquid phase separation has been implicated not only in membraneless intracellular organization but also in many biochemical processes, including transcription, translation, and cellular signaling. Here, we present a historical background of biological phase separation and survey current work on nuclear organization and its connection to DNA phase separation from the perspective of DNA sequence, structure, and genomic context.
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