Polygenic Scores for Neuropsychiatric Traits and White Matter Microstructure in the Pediatric Population.

Affiliation

Generation R Study Group, Erasmus University Medical Center, Rotterdam, The Netherlands; Department of Child and Adolescent Psychiatry, Erasmus University Medical Center, Rotterdam, The Netherlands; Department of Radiology, Erasmus University Medical Center, Rotterdam, The Netherlands. Electronic address: [Email]

Abstract

Genome-wide association studies have identified numerous genetic variants that predispose to neuropsychiatric traits. Identification of mechanisms in the brain that underlie these associations is essential for understanding manifestations of genetic predisposition within the general population. Here, we investigated the association between polygenic scores (PGSs) for seven neuropsychiatric traits and white matter microstructure of the brain on diffusion tensor imaging in the pediatric population.

Keywords

Children,Cognition,DTI,Polygenic scores,Psychiatric disorders,White matter,