Precipitation of Soluble Uric Acid Is Necessary for In Vitro Activation of the NLRP3 Inflammasome in Primary Human Monocytes.

Affiliation

From the Brighton and Sussex Medical School, University of Sussex, Brighton, UK. [Email]

Abstract

To investigate the effects of soluble uric acid (UA) on expression and activation of the NOD-like receptor (NLR) pyrin domain containing protein 3 (NLRP3) inflammasome in human monocytes to elucidate the role of hyperuricemia in the pathogenesis of gout.

Keywords

GOUT,INFLAMMASOMES,INFLAMMATION,MONOCYTES,REACTIVE OXYGEN SPECIES,URIC ACID,