Predictors of responders to mononuclear stem cell-based therapeutic angiogenesis for no-option critical limb ischemia.


Department of Vascular Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, China. [Email]


Although the mononuclear cell (MNC) transplantation could theoretically induce therapeutic angiogenesis in the patients with no-option critical limb ischemia (NO-CLI), the clinical responses to this approach are inconsistent among different clinical trials. The purpose of this study was to identify the prognostic factors of responders and develop a predictive nomogram to guide patient selection.


Critical limb ischemia,Mononuclear cell transplantation,Nomogram,Predictive analysis,Therapeutic angiogenesis,