Prevalence of Cryptosporidium in dairy cattle in China during 2008-2018: A systematic review and meta-analysis.

Affiliation

College of Animal Science and Technology, Jilin Agricultural University, Changchun, Jilin Province, 130118, PR China. Electronic address: [Email]

Abstract

Cryptosporidium is the causative agent of cryptosporidiosis. Cryptosporidium not only has a worldwide distribution, but also can infect various hosts, including dairy cattle and humans. Although numerous researches on Cryptosporidium infection in cattle have been conducted, no nationwide study on the prevalence of Cryptosporidium infection in dairy cattle in mainland China was carried out. In this meta-analysis, five databases, including PubMed, ScienceDirect, China National Knowledge Infrastructure (CNKI), Chongqing VIP, and Wanfang, were used to search for published papers regarding Cryptosporidium infection in dairy cattle in China from inception to February 25, 2019. Our study obtained 60 eligibility studies that reported Cryptosporidium infection in dairy cattle. We estimated the pooled Cryptosporidium prevalence to be 17.0% (3,901/33,313), with 16.9% (722/5,191) in Central China, 17.4% (959/6,162) in Eastern China, 29.8% (404/2,021) in Northeastern China, 15.7% (227/2,344) in Northern China, 15.8% (1,042/11,452) in Northwestern China, 9.5% (494/5,758) in Southern China, and 13.7% (53/385) in Southwestern China. The pooled prevalence of Cryptosporidium in before 2000 group (28.0%, 944/3,417) was significantly higher than in 2000-2010 group (11.1%, 384/3,643) and after 2010 group (13.7%, 2,134/22,411). Cattle with the age of ≤ 12 months (22.5%, 2,142/12,948) had a significantly higher prevalence than those of > 12 months (9.5%, 840/10,282). The pooled prevalence of Cryptosporidium in different seasons ranged from 8.2% (343/4,552) in Autumn to 19.5% (285/1,570) in Winter. Diarrhea cattle (38%, 133/477) had a higher Cryptosporidium prevalence than non-diarrhea cattle (13.0%, 367/2423). The pooled prevalence of Cryptosporidium in different provinces was various, with the highest (35.6%, 355/1,667) in Heilongjiang province, and the lowest (4.3%, 15/440) in Tianjin province. The univariate meta-regression analyses indicated that the collection year (P = 0.002) and age of cattle (P = 0.001) might be sources of heterogeneity. This systematic review suggests that China is a country where cryptosporidiosis frequently occurs in cattle. Due to the particular relationship between dairy cattle and feeder, further research is required to investigate the links between cattle ownership and Cryptosporidium infection.

Keywords

Cryptosporidium,Dairy cattle,Mainland China,Meta-analysis,