Área de Fisiopatología, Departamento de Patología, Facultad de Ciencias Médicas, Universidad Nacional de Cuyo, Mendoza, Argentina; IMBECU-CONICET (Instituto de Medicina y Biología Experimental de Cuyo - Consejo Nacional de Investigaciones Científicas y Técnicas), Argentina; Hospital Pediátrico Humberto J. Notti, Servicio de Nefrología, Ministerio de Salud, Mendoza, Argentina. Electronic address: [Email]
The inflammatory response of the host to Shiga toxin and/or lipopolysaccharide (LPS) of Escherichia coli (E. coli) is included in (HUS). The TLR4-LPS complex is internalized and TLR4 induced inflammatory signaling is stopped by targeting the complex for degradation. Rab7b, a small guanosine triphosphatase (GTPase) expressed in monocytes, regulates the later stages of the endocytic pathway.
