Rearranged clerodane diterpenoid from Tinospora crispa.

Affiliation

Parveen A(1)(2)(3), Huang Y(1)(4), Fantoukh O(1)(2)(5), Alhusban M(1)(2), Raman V(1), Wang YH(1), Wang W(4), Ali Z(1), Khan IA(1)(2).
Author information:
(1)National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, MS, USA.
(2)Department of Biomolecular Sciences, Division of Pharmacognosy, School of Pharmacy, The University of Mississippi, University, MS, USA.
(3)University of Science & Technology, Havelian, KPK, Pakistan.
(4)TCM and Ethnomedicine Innovation & Development Laboratory, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, Hunan, China.
(5)Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.

Abstract

A new rearranged clerodane diterpenoid, tinocrispide was isolated from the stems of Tinospora crispa along with thirteen known compounds including eight clerodane diterpenoids. Among the known compounds baenzigeride A, (6S, 9 R)-vomifoliol and steponine are being reported for the first time from T. crispa. Their structures were elucidated by 1 D and 2 D NMR and confirmed by HRESIMS. The 13C NMR data of borapetol A has been revised.