Role of epicardial adipose tissue NPR-C in acute coronary syndrome.

Affiliation

UGC Área del Corazón, Instituto de Investigación Biomédica de Málaga -IBIMA, Complejo Hospitalario de Málaga (Virgen de la Victoria) / Universidad de Málaga, Centro de Investigación Biomédica en Red Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III, Málaga, Spain. Electronic address: [Email]

Abstract

It has been suggested that epicardial adipose tissue (EAT) thermogenesis plays a role in coronary artery disease (CAD). Recent evidence indicates that natriuretic peptide receptors (NPRs) are critical for thermogenesis. We determined the expression and signaling of NPRs in EAT in the context of CAD progression and their association with brown fat-related genes, such as uncoupling protein 1 (UCP1) and peroxisome proliferator-activated receptor gamma coactivator alpha (PGC1α).

Keywords

Acute coronary syndrome,Epicardial adipose tissue,Human,NPR-C,brown-like fat genes,