Roles of the Amygdala and Basal Forebrain in Defense: a Reply to Luyck Et al. and Implications for Defensive Action.


Experimental Psychopathology and Treatment Section, Behavioural Science Institute, Radboud University, Nijmegen, The Netherlands. [Email]


The commentary by Luyck and colleagues on our paper provides many stimulating viewpoints and interpretations of our original study on dissociable responses in the amygdala and bed nucleus of the stria terminalis in threat processing. Here, we reply to some of the points raised and while agreeing with most of the comments also provide some alternative viewpoints. We end by putting forward a research agenda for how to further investigate the roles of these regions in threat processing, with an emphasis on studying their roles in defensive action.


Amygdala,Anxiety,Anxiety disorders,Avoidance,Bed nucleus of the stria terminalis,Defensive,Defensive action,Defensive reaction,Fear,Nucleus accumbens,Threat,Threat avoidance,Threat imminence,Translational,

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