Rosa x hybrida extracts with dual actions: Antiproliferative effects against tumour cells and inhibitor of Alzheimer disease.

Affiliation

Rivas-García L(1), Quiles JL(2), Roma-Rodrigues C(3), Raposo LR(3), Navarro-Hortal MD(4), Romero-Márquez JM(4), Esteban-Muñoz A(5), Varela-López A(4), García LC(6), Cianciosi D(7), Forbes Hernández TY(8), Battino M(9), Llopis J(10), Fernandes AR(11), Baptista PV(3), Sánchez-González C(12).
Author information:
(1)UCIBIO, Departamento Ciências da Vida, Faculdade de Ciências e Tecnologia, Universidade NOVA de Lisboa, Campus Caparica, 2829-516, Caparica, Portugal; Biomedical Research Centre, Institute of Nutrition and Food Technology "José Mataix Verdú", Department of Physiology, Faculty of Pharmacy, University of Granada, Avda. del Conocimiento s/n, 18100, Armilla, Granada, Spain.
(2)Biomedical Research Centre, Institute of Nutrition and Food Technology "José Mataix Verdú", Department of Physiology, Faculty of Pharmacy, University of Granada, Avda. del Conocimiento s/n, 18100, Armilla, Granada, Spain; Research group on Food, Nutritional Biochemistry and Health, Universidad Europea del Atlántico, 39011, Santander, Spain.
(3)UCIBIO, Departamento Ciências da Vida, Faculdade de Ciências e Tecnologia, Universidade NOVA de Lisboa, Campus Caparica, 2829-516, Caparica, Portugal.
(4)Biomedical Research Centre, Institute of Nutrition and Food Technology "José Mataix Verdú", Department of Physiology, Faculty of Pharmacy, University of Granada, Avda. del Conocimiento s/n, 18100, Armilla, Granada, Spain.
(5)Departament of Nutrition and Bromatology, University of Granada, 18071, Granada, Spain.
(6)Innoflower, S.L, 55014, Zaragoza, Spain.
(7)Dipartimento di Scienze Cliniche Specialistiche e Odontostomatologiche - Università Politecnica delle Marche, Via Ranieri 65, 60130, Ancona, Italy.
(8)Nutrition and Food Science Group, Department of Analytical and Food Chemistry, CITACA, CACTI, University of Vigo - Vigo Campus, 32004, Ourense, Spain.
(9)Dipartimento di Scienze Cliniche Specialistiche e Odontostomatologiche - Università Politecnica delle Marche, Via Ranieri 65, 60130, Ancona, Italy; International Research Center for Food Nutrition and Safety, Jiangsu University, Zhenjiang, 212013, China.
(10)Biomedical Research Centre, Institute of Nutrition and Food Technology "José Mataix Verdú", Department of Physiology, Faculty of Pharmacy, University of Granada, Avda. del Conocimiento s/n, 18100, Armilla, Granada, Spain; Sport and Health Research Centre. University of Granada, C/. Menéndez Pelayo 32, 18016, Armilla, Granada, Spain.
(11)UCIBIO, Departamento Ciências da Vida, Faculdade de Ciências e Tecnologia, Universidade NOVA de Lisboa, Campus Caparica, 2829-516, Caparica, Portugal. Electronic address: [Email]
(12)Biomedical Research Centre, Institute of Nutrition and Food Technology "José Mataix Verdú", Department of Physiology, Faculty of Pharmacy, University of Granada, Avda. del Conocimiento s/n, 18100, Armilla, Granada, Spain; Sport and Health Research Centre. University of Granada, C/. Menéndez Pelayo 32, 18016, Armilla, Granada, Spain. Electronic address: [Email]

Abstract

Edible flowers are being used as a new ingredient in modern gastronomy. Recently, these products have also gained interest as an important source of phenolic compounds with potential for biomedical applications. The present work studied a methanolic extract of Rosa x hybrida in which 35 individual phenolic compounds were identified. The extract has been evaluated for its antiproliferative properties in ovarian carcinoma cells. Results showed that the antiproliferative effect was associated with the induction of autophagy and apoptosis with the concomitant ROS increase probably related to mitochondria dysfunction. These antiproliferative effects might be associated with some components of the extract such as quercetin. The extract did not induce damage in healthy cells and that it was able to improve the wound healing activity. The present study also evaluated the properties of the mentioned extract in vivo in C. elegans. Tests demonstrated a lack of toxicity in the worm model. Promising results have been obtained in transgenic strains of C. elegans that produce human beta amyloid peptide, suggesting the possible utility of the extract from the point of view of Alzheimer disease. Altogether, results suggest that Rosa x hybrida extracts could be a new tool for the development of functional foods.