Routine Early Antibiotic Use in SymptOmatic Preterm Neonates: A Pilot Randomized Controlled Trial.

Affiliation

Ruoss JL(1), Bazacliu C(2), Russell JT(3), Cruz D(2), Li N(2), Gurka MJ(4), Filipp SL(4), Polin RA(5), Triplett EW(3), Neu J(2).
Author information:
(1)Division of Neonatology, Department of Pediatrics, University of Florida, Gainesville, FL. Electronic address: [Email]
(2)Division of Neonatology, Department of Pediatrics, University of Florida, Gainesville, FL.
(3)Department of Microbiology and Cell Science, Institute of Food and Agricultural Sciences, University of Florida, Gainesville, FL.
(4)Department of Health Outcomes and Biomedical Informatics, College of Medicine, University of Florida, Gainesville, FL.
(5)Department of Pediatrics, College of Physicians and Surgeons, Columbia University, New York, NY.

Abstract

We enrolled 98 infants (gestational age <33 weeks) in a pilot randomized trial of antibiotics vs no antibiotics; 55 were randomized (lower maternal infectious risk; symptoms expected for gestation). Adverse events did not differ significantly between the randomization arms. This trial establishes a framework for a larger multicentered trial.