Safety and efficacy of traditional Chinese medicine, Qiaoshao formula, combined with dapoxetine in the treatment of premature ejaculation: An open-label, real-life, retrospective multicentre study in Chinese men.

Affiliation

Guo J(1), Wang F(1), Zhou Q(2), Geng Q(3), Gao Q(1), Zhang R(4), Zhang C(5), Xuan Z(6), Cai J(7), Bin B(8), Han Q(9), Guo B(10)(11), Yan B(1), Zhang J(1), Colonnello E(12), Jannini EA(12)(13)(14)(15)(16).
Author information:
(1)Department of Andrology, Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing, China.
(2)Department of Andrology, The First Hospital of Hunan University of Chinese Medicine, Changsha, China.
(3)Department of Andrology, The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
(4)Department of Andrology, Heilongjiang University of Traditional Chinese Medicine, Harbin, China.
(5)Department of Andrology, Yunnan Provincial Hospital of Traditional Chinese Medicine, Kunming, China.
(6)Department of Andrology, Shunyi Hospital of Traditional Chinese Medicine, Beijing, China.
(7)Department of Urology, The Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
(8)Department of Andrology, The First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning, China.
(9)Department of Andrology, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, China.
(10)Department of Urology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, China.
(11)Graduate School of Peking Union Medical College, Beijing, China.
(12)Chair of Endocrinology and Medical Sexology
(ENDOSEX), Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
(13)Visiting Professor at the Department of Andrology, First Affiliated Hospital, Sun Yat-sen University School of Medicine, Guangzhou, China.
(14)Visiting Professor at the Department of Andrology, First Affiliated Hospital, Anhui Medical University, Hefei, China.
(15)Visiting Professor at the Department of Urology, Shanghai General Hospital, Jiao Tong University School of Medicine, Shanghai, China.
(16)Academic Advisor, First Teaching Hospital, Tianjin University of Traditional Chinese Medicine, Tianjin, China.

Abstract

To evaluate the safety and efficacy of Chinese medicine, Qiaoshao formula combined with dapoxetine was used for the treatment of premature ejaculation in a real-life setting. Nine hundred and five males diagnosed with premature ejaculation were reviewed in this retrospective cohort study. We divided the patients into two groups: dapoxetine alone and Qiaoshao formula combined with dapoxetine according to actual interventions provided to patients in clinics. The perceived intravaginal ejaculation latency time and the premature ejaculation profile measures markedly improved in both groups. However, in men with severe premature ejaculation (baseline perceived intravaginal ejaculation latency time <1 min) and those with baseline age ≤30 years, the perceived intravaginal ejaculation latency time was slightly but significantly longer with combined therapy than with dapoxetine alone (p < .05). Therefore, combined therapy involving the Qiaoshao formula and dapoxetine proved to safe as well as effective for treating premature ejaculation while prolonging the perceived intravaginal ejaculation latency time, which significantly improved the overall satisfaction of the patient and likely that of the couple.