Serum Calcium and Melatonin Levels in Neonates Undergoing Phototherapy.

Affiliation

Vigneshwar NKV(1), Basu S(2), Naithani M(3), Vivekanand N(1), Chacham S(1), Singh P(4).
Author information:
(1)Department of Pediatrics, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.
(2)Department of Neonatology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, 249203, India.
(3)Department of Biochemistry, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.
(4)Department of Neonatology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, 249203, India. [Email]

Abstract

Phototherapy-induced hypocalcemia has been postulated to result from a decline in serum melatonin levels. The present observational study evaluated the effects of phototherapy on serum calcium and melatonin levels, and assessed their correlation, if any. Eighty-nine neonates with a total serum bilirubin levels of 14.1 ± 2.8 mg/dL were recruited at the mean age of 51.9 ± 21.7 h. After a median interquartile range (IQR) duration of phototherapy for 24.0 (24-25.5) h, serum calcium levels decreased significantly, from 9.6 ± 0.8 to 9.4 ± 0.6 mg/dL; p = 0.02, leading to asymptomatic hypocalcemia in 2.2% of the neonates. Median (IQR) serum melatonin levels also decreased from 187.8 (133.5-227.6) to 176.3 (145.6-202.5) pg/mL after phototherapy, the difference being statistically insignificant. No significant correlation was documented between the duration of phototherapy with calcium and melatonin levels. The authors conclude that phototherapy resulted in a small but significant reduction of serum calcium levels without any significant correlation with serum melatonin.