Silver nanoparticle/capecitabine for breast cancer cell treatment.

Affiliation

Sivas Cumhuriyet University, Faculty of Pharmacy, Department of Biochemistry, Sivas, Turkey. Electronic address: [Email]

Abstract

This study aimed to evaluate antiproliferative and proapoptotic effects of Capecitabine bonded silver particles on human breast cancer cells (MCF-7). Different sizes of Ag NPs (in sizes 5, 10, 15, 30 nm) were synthesized. The characterization of silver and drug-bonded silver nanoparticles was performed through UV-VIS, FTIR, and SEM analysis. Silver and drug-bonded silver nanoparticles were measured by zetasizer. Antiproliferative and proapoptotic effects of capecitabine, silver and drug-bonded silver nanoparticles were evaluated using XTT, Anneksin V, respectively. According to the results, silver nanoparticles of 10 nm size have shown the lowest toxic effect. Drug-bonded nanoparticles significantly increased the number of early and late apoptotic cells on MCF-7 cells.

Keywords

Apoptosis,Breast cancer (MCF-7),Capecitabine,Silver nanoparticles,

OUR Recent Articles