Single-dose administration and the influence of the timing of the booster dose on immunogenicity and efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine: a pooled analysis of four randomised trials.

Affiliation

Collaborators: Aban M, Abeyskera KWM, Aboagye J, Adam M, Adams K, Adamson JP, Adewatan G, Adlou S, Ahmed K, Akhalwaya Y, Akhalwaya S, Alcock A, Ali A, Allen ER, Allen L, Alvernaz FB, Amorim FS, Andrade CS, Andritsou F, Anslow R, Arbe-Barnes EH, Ariaans MP, Arns B, Arruda L, Assad L, Azi PA, Azi LA, Babbage G, Bailey C, Baker KF, Baker M, Baker N, Baker P, Baleanu I, Bandeira D, Bara A, Barbosa MAS, Barker D, Barlow GD, Barnes E, Barr AS, Barrett JR, Barrett J, Barrett K, Bates L, Batten A, Beadon K, Beales E, Beckley R, Belij-Rammerstorfer S, Bell J, Bellamy D, Belton S, Berg A, Bermejo L, Berrie E, Berry L, Berzenyi D, Beveridge A, Bewley KR, Bharaj I, Bhikha S, Bhorat AE, Bhorat ZE, Bijker EM, Birch S, Birch G, Birchall K, Bird A, Bird O, Bisnauthsing K, Bittaye M, Blackwell L, Blacow R, Bletchly H, Blundell CL, Blundell SR, Bodalia P, Bolam E, Boland E, Bormans D, Borthwick N, Bowring F, Boyd A, Bradley P, Brenner T, Bridges-Webb A, Brown P, Brown C, Brown-O'Sullivan C, Bruce S, Brunt E, Budd W, Bulbulia YA, Bull M, Burbage J, Burn A, Buttigieg KR, Byard N, Cabrera Puig I, Calvert A, Camara S, Cao M, Cappuccini F, Cardona R, Cardoso JR, Carr M, Carroll MW, Carson-Stevens A, Carvalho YM, Casey HR, Cashen P, Castro TRY, Castro LC, Cathie K, Cavey A, Cerbino-Neto J, Cezar LFF, Chadwick J, Chanice C, Chapman D, Charlton S, Cheliotis KS, Chelysheva I, Chester O, Chiplin E, Chita S, Cho JS, Cifuentes L, Clark E, Clark M, Colin-Jones R, Collins SLK, Colton H, Conlon CP, Connarty S, Coombes N, Cooper C, Cooper R, Cornelissen L, Corrah T, Cosgrove CA, Costa FB, Cox T, Crocker WEM, Crosbie S, Cullen D, Cunha DRMF, Cunningham CJ, Cuthbertson FC, da Costa DM, Da Guarda SNF, da Silva LP, da Silva Moraes AC, Damratoski BE, Danos Z, Dantas MTDC, Datoo MS, Datta C, Davids M, Davies SL, Davies K, Davies H, Davies S, Davies J, Davis EJ, Davis J, de Carvalho JAM, De Jager J, de Jesus Jnr S, De Oliveira Kalid LM, Dearlove D, Demissie T, Desai A, Di Marco S, Di Maso C, Dinesh T, Docksey C, Dong T, Donnellan FR, Dos Santos TG, Dos Santos TG, Dos Santos EP, Douglas N, Downing C, Drake J, Drake-Brockman R, Drury R, Du Plessis J, Dunachie SJ, Duncan A, Easom NJW, Edwards M, Edwards NJ, Edwards F, El Muhanna OM, Elias SC, Ellison-Handley B, Elmore MJ, English MR, Esmail A, Essack YM, Farooq M, Fedosyuk S, Felle S, Ferguson S, Ferreira Da Silva C, Field S, Fisher R, Fletcher J, Fofie H, Fok H, Ford KJ, Fothergill R, Fowler J, Fraiman PHA, Francis E, Franco MM, Frater J, Freire MSM, Fry SH, Fudge S, Furlan Filho R, Furze J, Fuskova M, Galian-Rubio P, Garlant H, Gavrila M, Gibbons KA, Gilbride C, Gill H, Godwin K, Gokani K, Gonçalves MLF, Gonzalez IGS, Goodall J, Goodwin J, Goondiwala A, Gordon-Quayle K, Gorini G, Goyanna A, Grab J, Gracie L, Green J, Greenwood N, Greffrath J, Groenewald MM, Gunawardene A, Gupta G, Hackett M, Hallis B, Hamaluba M, Hamilton E, Hamlyn J, Hammersley D, Hanrath AT, Hanumunthadu B, Harris SA, Harris C, Harrison TD, Harrison D, Harris-Wright TA, Hart TC, Hartnell B, Haughney J, Hawkins S, Hayano LYM, Head I, Heath PT, Henry JA, Hermosin Herrera M, Hettle DB, Higa C, Hill J, Hodges G, Hodgson S, Horne E, Hou MM, Houlihan CF, Howe E, Howell N, Humphreys J, Humphries HE, Hurley K, Huson C, Hyams C, Hyder-Wright A, Ikram S, Ishwarbhai A, Iveson P, Iyer V, Jackson F, Jackson S, Jaumdally S, Jeffers H, Jesudason N, Jones C, Jones C, Jones K, Jones E, Jorge MR, Joshi A, Júnior EAMS, Kailath R, Kana F, Kar A, Karampatsas K, Kasanyinga M, Kay L, Keen J, Kellett Wright J, Kelly EJ, Kelly D, Kelly DM, Kelly S, Kerr D, Khan L, Khozoee B, Khurana A, Kidd S, Killen A, Kinch J, Kinch P, King LDW, King TB, Kingham L, Klenerman P, Kluczna DM, Knapper F, Knight JC, Knott D, Koleva S, Lages PM, Lang M, Lang G, Larkworthy CW, Larwood JPJ, Law R, Lawrie AM, Lazarus EM, Leach A, Lees EA, Lelliott A, Lemm NM, Lessa AER, Leung S, Li Y, Lias AM, Liatsikos K, Linder A, Lipworth S, Liu S, Liu X, Lloyd A, Lloyd S, Loew L, Lopez Ramon R, Lora LB, Luz KG, MacDonald JC, MacGregor G, Madhavan M, Mainwaring DO, Makambwa E, Makinson R, Malahleha M, Malamatsho R, Mallett G, Manning N, Mansatta K, Maoko T, Marinou S, Marlow E, Marques GN, Marriott P, Marshall RP, Marshall JL, Masenya M, Masilela M, Masters SK, Mathew M, Matlebjane H, Matshidiso K, Mazur O, Mazzella A, McCaughan H, McEwan J, McGlashan J, McInroy L, McRobert N, McSwiggan S, Megson C, Mehdipour S, Meijs W, Mendonça RNÕ, Mentzer AJ, Mesquita ACF, Miralhes P, Mirtorabi N, Mitton C, Mnyakeni S, Moghaddas F, Molapo K, Moloi M, Moore M, Moran M, Morey E, Morgans R, Morris SJ, Morris S, Morrison H, Morselli F, Morshead G, Morter R, Mottay L, Moultrie A, Moyo N, Mpelembue M, Msomi S, Mugodi Y, Mukhopadhyay E, Muller J, Munro A, Murphy S, Mweu P, Myerscough C, Naik G, Naker K, Nastouli E, Ndlovu B, Nikolaou E, Njenga C, Noal HC, Noé A, Novaes G, Nugent FL, Nunes GLA, O'Brien K, O'Connor D, Oelofse S, Oguti B, Olchawski V, Oldfield NJ, Oliveira MG, Oliveira C, Oliveira ISQ, Oommen-Jose A, Oosthuizen A, O'Reilly P, O'Reilly PJ, Osborne P, Owen DRJ, Owen L, Owens D, Owino N, Pacurar M, Paiva BVB, Palhares EMF, Palmer S, Parracho HMRT, Parsons K, Patel D, Patel B, Patel F, Patrick-Smith M, Payne RO, Peng Y, Penn EJ, Pennington A, Peralta Alvarez MP, Pereira Stuchi BP, Perez AL, Perinpanathan T, Perring J, Perumal R, Petkar SY, Philip T, Phillips J, Phohu MK, Pickup L, Pieterse S, Pinheiro JM, Piper J, Pipini D, Plank M, Plant S, Pollard S, Pooley J, Pooran A, Poulton I, Powers C, Presa FB, Price DA, Price V, Primeira MR, Proud PC, Provstgaard-Morys S, Pueschel S, Pulido D, Quaid S, Rabara R, Radia K, Rajapaska D, Rajeswaran T, Ramos L, Ramos ASF, Ramos Lopez F, Rampling T, Rand J, Ratcliffe H, Rawlinson T, Rea D, Rees B, Resuello-Dauti M, Reyes Pabon E, Rhead S, Riaz T, Ricamara M, Richards A, Richter A, Ritchie N, Ritchie AJ, Robbins AJ, Roberts H, Robinson RE, Roche S, Rollier C, Rose L, Ross Russell AL, Rossouw L, Royal S, Rudiansyah I, Ryalls K, Sabine C, Saich S, Sale JC, Salman AM, Salvador N, Salvador S, Sampaio MD, Samson AD, Sanchez-Gonzalez A, Sanders H, Sanders K, Santos E, Santos Guerra MFS, Satti I, Saunders JE, Saunders C, Sayed ABA, Schim van der Loeff I, Schmid AB, Schofield E, Screaton GR, Seddiqi S, Segireddy RR, Senger R, Serrano S, Shaik I, Sharpe HR, Sharrocks K, Shaw R, Shea A, Sheehan E, Shepherd A, Shiham F, Silk SE, Silva-Reyes L, Silveira LBTD, Silveira MBV, Singh N, Sinha J, Skelly DT, Smith DC, Smith N, Smith HE, Smith DJ, Smith CC, Soares AS, Solórzano C, Sorio GL, Sorley K, Sosa-Rodriguez T, Souza CMCDL, Souza BSDF, Souza AR, Souza Lopez T, Sowole L, Spencer AJ, Spoors L, Stafford L, Stamford I, Stein R, Stockdale L, Stockwell LV, Strickland LH, Stuart A, Sturdy A, Sutton N, Szigeti A, Tahiri-Alaoui A, Tanner R, Taoushanis C, Tarr AW, Tarrant R, Taylor K, Taylor U, Taylor IJ, Taylor J, Te Water Naude R, Templeton K, Themistocleous Y, Themistocleous A, Thomas M, Thomas K, Thomas TM, Thombrayil A, Thompson J, Thompson F, Thompson A, Thompson A, Thompson K, Thornton-Jones V, Thotusi LHS, Tighe PJ, Tinoco LA, Tiongson GF, Tladinyane B, Tomasicchio M, Tomic A, Tonks S, Towner J, Tran N, Tree JA, Trillana G, Trinham C, Trivett R, Truby A, Tsheko BL, Tubb P, Turabi A, Turner R, Turner C, Turner N, Tyagi B, Ulaszewska M, Underwood BR, van Eck S, Varughese R, Verbart D, Verheul MK, Vichos I, Vieira TA, Walker G, Walker L, Wand ME, Wardell T, Warimwe GM, Warren SC, Watkins B, Watson MEE, Watson E, Webb S, Webster A, Welch J, Wellbelove Z, Wells JH, West AJ, White B, White C, White R, Williams P, Williams RL, Willingham S, Winslow R, Woods D, Woodyer M, Worth AT, Wright D, Wroblewska M, Yao A, Yim YTN, Zambrano MB, Zimmer RL, Zizi D, Zuidewind P.
Author information:
(1)Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.
(2)Institute of Global Health, University of Siena, Siena, Italy; Department of Paediatrics, University of Oxford, Oxford, UK.
(3)South African Medical Research Council Vaccines and Infectious Diseases Analytics Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Department of Science and Innovation/National Research Foundation South African Research Chair Initiative in Vaccine Preventable Diseases Unit, University of the Witwatersrand, Johannesburg, South Africa.
(4)Department of Pediatrics, Universidade Federal de São Paulo, São Paulo, Brazil.
(5)Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
(6)Family Centre for Research with Ubuntu, Department of Paediatrics, University of Stellenbosch, Cape Town, South Africa.
(7)Soweto Clinical Trials Centre, Soweto, South Africa.
(8)Perinatal HIV Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
(9)Department of Clinical Sciences, Liverpool School of Tropical Medicine and Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK.
(10)Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, UK; Department of Infection and Tropical Medicine, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.
(11)Division of Pulmonology, Groote Schuur Hospital and the University of Cape Town, Cape Town, South Africa; Faculty of Infectious and Tropical Diseases, Department of Immunology and Infection, London School of Hygiene & Tropical Medicine, London, UK.
(12)Department of Infection and Tropical Medicine, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK; Translational and Clinical Research Institute, Immunity and Inflammation Theme, Newcastle University, Newcastle upon Tyne, UK.
(13)Wits Reproductive Health and HIV Institute, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
(14)NIHR Southampton Clinical Research Facility and Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, University of Southampton, Southampton, UK; Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, UK.
(15)School of Population Health Sciences, University of Bristol and University Hospitals Bristol and Weston NHS Foundation Trust, UK.
(16)St George's Vaccine Institute, St George's, University of London, London, UK.
(17)Department of Infection, Guy's and St Thomas' NHS Foundation Trust, St Thomas' Hospital, London, UK; MRC Clinical Trials Unit, University College London, London, UK.
(18)Clinical BioManufacturing Facility, University of Oxford, Oxford, UK.
(19)NIHR/Wellcome Trust Clinical Research Facility, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
(20)AstraZeneca BioPharmaceuticals, Cambridge, UK.
(21)Severn Pathology, North Bristol NHS Trust, Bristol, UK.
(22)NIHR UCLH Clinical Research Facility and NIHR UCLH Biomedical Research Centre, London, UK.
(23)Department of Infection, Hull University Teaching Hospitals NHS Trust, Hull, UK.
(24)Escola Bahiana de Medicina e Saúde Pública, Salvador, Braziland Hospital São Rafael, Salvador, Brazil; Instituto D'Or, Salvador, Brazil.
(25)Universidade Federal do Rio Grande do Norte, Natal, Brazil.
(26)London Northwest University Healthcare, Harrow, UK.
(27)Setshaba Research Centre, Pretoria, South Africa.
(28)Hospital Quinta D'Or, Rede D'Or, Rio De Janeiro, Brazil.
(29)NIHR Imperial Clinical Research Facility and NIHR Imperial Biomedical Research Centre, London, UK.
(30)Clinical Research Unit, Department of Clinical Medicine, Universidade Federal de Santa Maria, Santa Maria, Brazil.
(31)College of Medical, Veterinary & Life Sciences, Glasgow Dental Hospital & School, University of Glasgow, Glasgow, UK.
(32)Infectious Diseases Service, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
(33)Clinical Infection Research Group, Regional Infectious Diseases Unit, Western General Hospital, Edinburgh, UK.
(34)MRC-University of Glasgow Centre for Virus Research & Department of Infectious Diseases, Queen Elizabeth University Hospital, Glasgow, UK.
(35)Department of Medicine, University of Cambridge, UK; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
(36)Heart Lung Research Institute, Dept of Medicine, University of Cambridge and NIHR Cambridge Clinical Research Facility, Cambridge University Hospital and Royal Papworth NHS Foundation Trusts, Cambridge, UK.
(37)University of Nottingham and Nottingham University Hospitals NHS Trust, Nottingham, UK.
(38)Public Health Wales, Cardiff, Wales; Aneurin Bevan University Health Board, Newport, Wales.
(39)Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK. Electronic address: [Email]

Abstract

Erratum in Lancet. 2021 Mar 6;397(10277):880.