Small Molecule KRAS Agonist for Mutant KRAS Cancer Therapy.

Affiliation

Division of Cancer Biology, Department of Radiation Oncology, Emory University School of Medicine and Winship Cancer Institute of Emory University, Atlanta, GA, 30322, USA. [Email]

Abstract

Lung cancer patients with KRAS mutation(s) have a poor prognosis due in part to the development of resistance to currently available therapeutic interventions. Development of a new class of anticancer agents that directly targets KRAS may provide a more attractive option for the treatment of KRAS-mutant lung cancer.

Keywords

Agonist,Apoptosis,Autophagy,KRAS,NSCLC,Therapy,