Some naturally occurring compounds that increase longevity and stress resistance in model organisms of aging.

Affiliation

Department of Health Science, Universidad Autónoma Metropolitana, Iztapalapa, CP 09340, Mexico City, Mexico. [Email]

Abstract

Humans and other organisms show age-related signs of deterioration, which makes aging an interesting process to study. In the present work, we review the anti-aging evidence of several of the most promising natural compounds. Quercetin, rapamycin, resveratrol, spermidine, curcumin or sulforaphane administration increase longevity and stress resistance in model organisms such as yeasts, nematodes, flies and mice. Even more, rapamycin, resveratrol, and curcumin are currently in preclinical tests on the Interventions Testing Program of the National Institute on Aging due to their encouraging results in model organisms. The potential mechanisms underlying the beneficial effects of these compounds are briefly described.

Keywords

Aging models,Longevity,Natural compounds,Signaling pathways,Stress resistance,

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