Synthesis and Self-Assembly Properties of Bola-Amphiphilic Glycosylated Lipopeptide-Type Supramolecular Hydrogels Showing Colour Changes Along with Gel-Sol Transition.

Affiliation

Tsutsumi N(1), Ito A(2)(3), Ishigamori A(4), Ikeda M(5)(6), Izumi M(1)(4)(7)(8), Ochi R(1)(4)(7)(8).
Author information:
(1)Graduate School of Integrated Arts and Sciences, Kochi University, 2-5-1, Akebono-cho, Kochi 780-8520, Japan.
(2)School of Environmental Science and Engineering, Kochi University of Technology, Kami, Kochi 782-8502, Japan.
(3)Research Center for Molecular Design, Kochi University of Technology, Kami, Kochi 782-8502, Japan.
(4)Faculty of Science, Kochi University, 2-5-1, Akebono-cho, Kochi 780-8520, Japan.
(5)Department of Chemistry and Biomolecular Science, Faculty of Engineering, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.
(6)United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.
(7)Interdisciplinary Science Unit, Multidisciplinary Sciences Cluster, Research and Education Faculty, Kochi University, 2-5-1, Akebono-cho, Kochi 780-8520, Japan.
(8)Faculty of Science and Technology, Kochi University, 2-5-1, Akebono-cho, Kochi 780-8520, Japan.

Abstract

Supramolecular hydrogels formed by self-assembly of low-molecular-weight amphiphiles (hydrogelators) have attracted significant attention, as smart and soft materials. However, most of the observed stimuli-responsive behaviour of these supramolecular hydrogels are limited to gel-sol transitions. In this study, we present bola-amphiphilic glycosylated lipopeptide-type supramolecular hydrogelators that exhibit reversible thermochromism along with a gel-sol transition. The bola-amphiphiles have mono-, di-, tri- or tetra-phenylalanine (F) as a short peptide moiety. We investigate and discuss the effects of the number of F residues on the gelation ability and the morphology of the self-assembled nanostructures.