Synthesis and biological activities evaluation of sanjuanolide and its analogues.

Affiliation

School of Life Science, Shandong University of Technology, Zibo 255049, PR China. Electronic address: [Email]

Abstract

Sanjuanolide, psorachalcone A and its seven new analogues were synthesized via a combinatorial strategy by aldol reaction. In order to investigate the effect between electron density in π-conjugated systems and biological activities, several electron-withdrawing and electron-donating groups were introduced at C-4 and the phenolic hydroxyl groups of sanjuanolide. The two natural products and its seven new analogues were investigated for their inhibitory effects against five cancer cell lines. Moreover, the hydroxyisoprenyl group may be important to maintain the biological activities of sanjuanolide.

Keywords

Analogues,Biological activity,Hydroxyisoprenyl group,Isoprenylated chalcone,Natural product,