Systemic Regulation of Bone Marrow Stromal Cytokines After Severe Trauma.

Affiliation

Department of Surgery, Sepsis and Critical Illness Research Center, University of Florida Health, Gainesville, Florida. Electronic address: [Email]

Abstract

Traumatic injury generates a prolonged hypercatecholamine state that is associated with reduced growth of bone marrow erythroid progenitors mediated by the bone marrow stroma. The bone marrow stroma is made up of many cells including fibroblasts, which respond to inflammatory stimuli and alter the cytokine profile. We hypothesized that trauma plasma would increase bone marrow stromal fibroblast expression of interleukin-6 (IL-6), granulocyte colony-stimulating factor (G-CSF), erythropoietin (EPO), stem cell factor (SCF), and activation of nuclear factor kappa-light-chain-enhancer of activated B cells and correlate with injury severity and anemia.

Keywords

Bone marrow stroma,EPO,G-CSF,IL-6,SCF,

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