T-Lymphocyte-Based Renin Angiotensin System in Obesity.

Affiliation

Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy. Electronic address: [Email]

Abstract

Obesity can be associated with increased cardio-metabolic risk, but some subjects with obesity do not show metabolic impairment and escape this association. Low-grade inflammation (i.e., high sensitivity C-reactive protein [hsCRP] > 3 mg/dL) is associated with high cardiovascular risk in obesity. We investigated renin-angiotensin system (RAS) activity in cultured circulating T-cells in subjects with obesity with and without angiotensin II (Ang II) stimulation in the presence or absence of low-grade inflammation.

Keywords

Angiotensin II,Angiotensin-converting enzyme,Obesity,Renin-angiotensin system,T-cell,