Tellurium: A new active element for innovative multifunctional bioactive glasses.

Affiliation

Miola M(1), Massera J(2), Cochis A(3), Kumar A(3), Rimondini L(3), Vernè E(4).
Author information:
(1)Department of Applied Science and Technology, Politecnico di Torino, corso Duca degli Abruzzi 24, 10129 Torino, TO, Italy; PolitoBioMED Lab, Politecnico di Torino, Via Piercarlo Boggio 59, 10138 Torino, TO, Italy. Electronic address: [Email]
(2)Faculty of Medicine and Health Technology, Laboratory of Biomaterials and Tissue Engineering, Tampere University, Korkeakoulunkatu 3, 33720 Tampere, Finland.
(3)Department of Health Sciences, Università del Piemonte Orientale UPO, Via Solaroli 17, 28100 Novara, NO, Italy; Interdisciplinary Research Center of Autoimmune Diseases, Center for Translational Research on Autoimmune and Allergic Diseases-CAAD, Corso Trieste 15A, 28100 Novara, NO, Italy.
(4)Department of Applied Science and Technology, Politecnico di Torino, corso Duca degli Abruzzi 24, 10129 Torino, TO, Italy; PolitoBioMED Lab, Politecnico di Torino, Via Piercarlo Boggio 59, 10138 Torino, TO, Italy.

Abstract

Bioactive glasses have been widely investigated for their ability to release ions with therapeutic effect. In this paper, a silica based bioactive glass was doped with a low amount of tellurium dioxide (1 and 5 mol%) to confer antibacterial and antioxidant properties. The obtained glasses were characterized in terms of morphology, composition, structure, characteristic temperatures and in vitro bioactivity. Moreover, comprehensive analyses were carried out to estimate the cytocompatibility, the antibacterial and antioxidant properties of Te-doped glasses. The performed characterizations demonstrated that the Te insertion did not interfere with the amorphous nature of the glass, the substitution of SiO2 with TeO2 led to a slight decrease in Tg and a TeO2 amount higher than 1 mol% can induce a change in the primary crystal field. In vitro bioactivity test demonstrated the Te-doped glass ability to induce the precipitation of hydroxyapatite. Finally, the biological characterization showed a strong antibacterial and antioxidant effects of Te-containing glasses in comparison with the control glass, demonstrating that Te is a promising element to enhance the biological response of biomaterials.