Rodríguez JM(1), Fernández L(2), Verhasselt V(3). Author information:
(1)Department of Nutrition and Food Science, Complutense University of Madrid,
28040 Madrid, Spain.
(2)Department of Galenic Pharmacy and Food Technology, Complutense University of
Madrid, 28040 Madrid, Spain.
(3)School of Molecular Sciences, University of Western Australia, M310 Perth, WA
The gut is a pivotal organ in health and disease. The events that take place in the gut during early life contribute to the programming, shaping and tuning of distant organs, having lifelong consequences. In this context, the maternal gut plays a quintessence in programming the mammary gland to face the nutritional, microbiological, immunological, and neuroendocrine requirements of the growing infant. Subsequently, human colostrum and milk provides the infant with an impressive array of nutrients and bioactive components, including microbes, immune cells, and stem cells. Therefore, the axis linking the maternal gut, the breast, and the infant gut seems crucial for a correct infant growth and development. The aim of this article is not to perform a systematic review of the human milk components but to provide an insight of their extremely complex interactions, which render human milk a unique functional food and explain why this biological fluid still truly remains as a scientific enigma.
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