The Role of Nicorandil in the Management of Chronic Coronary Syndromes in the Gulf Region.

Affiliation

Cheng K(1)(2), Alhumood K(3), El Shaer F(4)(5), De Silva R(6)(7).
Author information:
(1)Specialist Angina Service, Royal Brompton and Harefield NHS Foundation Trust, London, UK.
(2)Vascular Science Department, National Heart and Lung Institute, London, UK.
(3)Al Adan Hospital, Safat, Kuwait.
(4)Department of Cardiac Sciences, King Fahad Cardiac Center, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
(5)National Heart Institute, Cairo, Egypt.
(6)Specialist Angina Service, Royal Brompton and Harefield NHS Foundation Trust, London, UK. [Email]
(7)Vascular Science Department, National Heart and Lung Institute, London, UK. [Email]

Abstract

Chronic coronary syndromes (CCS) and stable angina are a growing clinical burden worldwide. This is of particular concern in the Gulf region given its high prevalence of cardiovascular risk factors, especially diabetes mellitus and smoking. Despite recommendations on the use of first- and second-line anti-anginal medication, management challenges remain. Current guidelines for pharmacologic treatment are not determined by the range of pathophysiological mechanisms of ischaemia and consequent angina, which may occur either in isolation or co-exist. In this article, we highlight the need to improve knowledge of the epidemiology of chronic coronary syndromes in the Middle East and Gulf region, and the need for studies of stratified pharmacologic approaches to improve symptomatic angina and quality of life in the large and growing number of patients with coronary artery disease from this region. We discuss the role of nicorandil, currently recommended as a second-line anti-anginal drug in CCS patients, and suggest that this may be a particularly useful add-on therapy for patients in the Gulf region.