Helping the return of people with social disorders, including ethanol consumption, are important research topics in the field of biological sciences, and there are many uncertainties about the efficacy of drug interventions and exercise training. The aim of this study was to investigate the effects short-term combination of curcumin and swimming on the improvement of spatial memory. Male Wistar rats (200-250 g) were randomly assigned into ethanol or dextrose groups. After 4 days of gavage, and withdrawn of consumption, they were affected by swimming intervention or curcumin supplementation within 2 weeks. Spatial memory was assessed in Morris Water Maze (MWM) apparatus by a single training session of eight trials. Furthermore, levels of BDNF were measured in hippocampal tissue by doing real time PCR. The results showed that binge ethanol drinking had no significant effect on the traveled distance [F(1,14) = 0.024; P > .05] and escape latency [F(1,14) = 0.648; P > .05] of reaching the platform. In the probe test, both the percentage of swimming time [t(14) = -4.621; P < .001] and distance [t(14) = -4.989; P < .001] in the target quadrant was significantly lower in the ethanol group than the dextrose group. On the other hand in reviewing the effect of curcumin and swimming exercise on learning and spatial memory, The percentage of swimming time was significantly higher in the swim+curcumin [P < .01], training [P < .05] and curcumin [P < .05] subgroups then the control subgroup. The percentage of distance traveled in the swim+curcumin subgroup [P < .001] and curcumin subgroup [P < .05] was significantly higher than the control subgroup. In addition, in the group of binge ethanol drinking, the percentage of swimming time and distance traveled in the target quadrant in the swim+curcumin subgroup was significantly higher than the control subgroup [P < .001]. There was a positive correlation between BDNF gene expression and the percentage of swimming time [P < .01] and the distance traveled in the target quadrant [P < .001] was observed. In conclusion, Binge ethanol drinking causes spatial memory deficiency by reduction of BDNF, and the combination of curcumin and swimming training improves impaired spatial memory after binge ethanol drinking.