The effect of spironolactone on cardiovascular function and markers of fibrosis in people at increased risk of developing heart failure: the heart 'OMics' in AGEing (HOMAGE) randomized clinical trial.


Collaborators: Atar D, Kober L, Dickstein K, Lange T.
Author information:
(1)Robertson Centre for Biostatistics, Institute of Health and Wellbeing, University of Glasgow, Glasgow Royal Infirmary, Glasgow G12 8QQ, UK.
(2)Université de Lorraine, Inserm, Centre d'Investigation Clinique Plurithématique 1433, CHRU de Nancy, F-CRIN INI-CRCT, Nancy, U1116, France.
(3)Department of Cardiology, Cortona Hospital, Arezzo, Italy.
(4)Department of Cardiology, University of Hull, Castle Hill Hospital, Cottingham, East Riding of Yorkshire, UK.
(5)Department of Cardiology, Maastricht University Medical Center, the Netherlands.
(6)Department of Internal Medicine and Cardiology, Campus Virchow Klinikum, Charité University Medicine Berlin, Berlin Institute of Health
(BIH), and German Centre for Cardiovascular research
(DZHK), Partner Site Berlin, Germany.
(7)Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Oxford Road, Manchester, UK.
(8)Centre for Prognosis Research, Institute for Primary Care and Health Sciences, Keele University, UK.
(9)German Heart Center Berlin, Germany.
(10)St. Vincent's University Healthcare Group, and School of Medicine, University College Dublin, Dublin, Ireland.
(11)Equipe obésité et insuffisance cardiaque, Université UPS, Inserm I2MC, Toulouse, UMR 1048, France.
(12)Studies Coordinating Centre, Research Unit Hypertension and Cardiovascular Epidemiology, Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium.
(13)Department of Diagnostic and Interventional Radiology, Universitatsklinikum Freiburg, Freiburg, Germany.
(14)Program of Cardiovascular Diseases, CIMA. Universidad de Navarra and IdiSNA, Pamplona, Spain CIBERCV, Carlos III Institute of Health, Madrid, Spain.
(15)Departments of Nephrology and Cardiology, Clínica Universidad de Navarra, Pamplona, Spain.
(16)Department of Cardiovascular Medicine, Istituto di Ricerche Farmacologiche "Mario Negri" - IRCCS, Milan, Italy.
(17)Fondation Force, Research and Consulting Department, EDDH, Centre de Médecine Préventive, Rue du Doyen Jacques Parisot, Vandoeuvre les Nancy, 54500, France.
(18)Department of Medical Statistics, London School of Hygiene and Tropical Medicine, London, UK.


Comment in Eur Heart J. 2021 Feb 11;42(6):697-699.