Division of Translational Research, Taipei Veterans General Hospital, Taipei, Taiwan; Institute of Clinical Medicine & Institute of Public Health, National Yang-Ming University, Taipei, Taiwan; College of Public Health, China Medical University, Taichung, Taiwan. Electronic address: [Email]
Obesity is worldwide epidemic given its rapid growth in global prevalence. Among the risk factors contributing to obesity, human gut microbiome recently emerges with unprecedented intimacy in host metabolism and inflammation. With the advances in sequencing technology, more and more detailed understandings towards the intricate relationships linking gut microbiome and obesity have been continuously disclosed. Herein, we review studies resolving associations between gut microbiome and obesity, and then mechanistic studies tackling the roles played by gut microbes in obesogenic physiology.