Khashkhusha A(1), Munir W(2), Bashir M(3), Idhrees M(4). Author information:
(1)University of Liverpool, Brownlow Hill, Liverpool, UK.
(2)Barts and the London School of Medicine and Dentistry, Queen Mary University
of London, London, UK.
(3)Department of Vascular Surgery, Royal Blackburn Teaching Hospital, Blackburn,
UK - [Email]
(4)Institute of Cardiac and Aortic Disorders, SRM Institutes for Medical Science
(SIMS Hospitals), Chennai, India.
Until recently thoracic aortic aneurysm (TAA) and abdominal aortic aneurysm (AAA) were correlated with atherosclerosis but following a range of cohort studies, a linkage proved unlikely. Instead, data from the Genome wide association study detected two common significantly correlated lncRNA loci: miRNA and the antisense non-coding RNA in the INK4 locus (ANRIL). lncRNAs are sometimes utilized by the body as transcription regulators and signaling molecules. This is crucial in cell transformation and embryology, including that of the mammalian heart. ANRIL, a 19 exon RNA sequence found in the chromosome 9p21 region, will be one of the main focuses of this paper. TAA and AAA have many differences due to their vessel walls but similarities in their gross anatomic structure prove a genetic correlated disease likely. ANRIL has a convincing potential to be used as an additive therapeutic tool in TAA and AAA. This is because Chr9p21 is independent of typical risk factors. However, it remains that further research and clinical studies are required before clinical translation. It is best to consider TAA and AAA separately as the underlying pathophysiology has some distinct differences. They are both commonly diagnosed late, and the hope is that genetic mutations (ANRIL) can act as a biomarker for a faster diagnosis, management and possible treatment alternative.
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