Korneev S(1), Garaliene J(2), Taylor G(2), Kemenes I(2), Kemenes G(2). Author information:
(1)Sussex Neuroscience, School of Life Sciences, University of Sussex, Brighton,
BN1 9QG, UK. [Email]
(2)Sussex Neuroscience, School of Life Sciences, University of Sussex, Brighton,
BN1 9QG, UK.
Long natural antisense transcripts (NATs) have been demonstrated in significant numbers in a variety of eukaryotic organisms. They are particularly prevalent in the nervous system suggesting their importance in neural functions. However, the precise physiological roles of the overwhelming majority of long NATs remain unclear. Here we report on the characterization of a novel molluscan nitric oxide synthase (NOS)-related long non-coding NAT (Lym-NOS1AS). This NAT is spliced and polyadenylated and is transcribed from the non-template strand of the Lym-NOS1 gene. We demonstrate that the Lym-NOS1AS is co-expressed with the sense Lym-NOS1 mRNA in a key neuron of memory network. Also, we report that the Lym-NOS1AS is temporally and spatially regulated by one-trial conditioning leading to long term memory (LTM) formation. Specifically, in the cerebral, but not in the buccal ganglia, the temporal pattern of changes in Lym-NOS1AS expression after training correlates with the alteration of memory lapse and non-lapse periods. Our data suggest that the Lym-NOS1AS plays a role in the consolidation of nitric oxide-dependent LTM.
OUR JOURNALS
Having over 250 Research scholars worldwide and more than 400 articles online with open access.
